tisdag 23 november 2021

Carnosine and Zinc L-Carnosine: A brief explanation

Carnosine is a dipeptide which consists of two amino acids - Histidine and Beta-Alanine.
Both amino acids is naturally found in the body but the second one in small quantity. One of the functions Carnosine have in the body is to transports long-chain fatty acids into the mitochondria so they can be used to produce energy within the cell.

Possible Effects of Carnosine
  • Decreasing AGE (* Advanced glycation end-products) = decreasing of cellular garbage.
  • Cellular garbage speeds up the aging process so by taking Carnoisine some antiaging effects can be obtained. 
  • It acts as an anti-oxidant
  • It makes the microconidia in the cells to function better.
  • It helps out with muscle contraction which makes it popular among body builders and other athletes.
In vitro there is a study showing that carnosine rejuvenate cells in lab, and flies that was given carnosine lived longer.

Natural sources: Fish and read meat. An average person would get 250 mg of Carnoisine by eating a normal amount of fish or read meat every day. According to Marcus Gitterly this is to less to have positive effects and therefore supplementation is recommended.

In humans there is an enzyme in the blood called carnosinase which cuts carnosine to the amino acids histidine and beta-alanine. This means that, if we consume carnosine it will break down into histidine and beta-alanine. So, when we know this, taking Carnosine as a pure product make now sense, therefore I recommend taking Beta-Alanine instead so that the body itself can create Carnosine. Furthermore Beta-Aline is cheaper to buy so it’s a double vin.

Carnoisine daily dose: 500 mg, 2 times per day, or
Beta-Alanine daily dose: 500 mg – 1 G.

Zinc L- Carnosine
Also know under the name Polaprezinc consists of 23% zinc and 77 % L-carnosine, although it is a molecule and not a mixture of L-Carnosine and Zink.

Effects: it can help out with increased gut permeability. Heals gastric ulcers, oral Mucositis (inflammation of the mouth mucosa), esophagitis (inflammation of the canal that connects throat and stomach), taste alteration and proctitis (inflamation of the last 6 inches of the rectum)

Zink is important for the cell growth and cell metabolism, DNA replication, transcription to RNA and protein synthesis.

Since Zink L-Carnoisine can help to restore increased gut permeability / leaky gut it’s a great supplement to take for people who suffers from autoimmune conditions, especially ulcerative colitis and crohns disease.

To buy Zink Carnosine with 10% discount from Iherb: USE this link (affilate)

Study on zinc-carnosine
Efficacy of zinc-carnosine chelate compound, Polaprezinc, enemas in patients with ulcerative colitis.

CONCLUSIONS from the stydy:
A zinc-carnosine chelate compound, PZ, enema may become a useful new add-on treatment to accelerate mucosal healing in UC

Study on zinc-carnosine 
Zinc carnosine, a health food supplement that stabilizes small bowel integrity and stimulates gut repair processes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856764/

Explanation from wikpedia

* Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars.[1] They can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer's disease.

For further info about Carnosine and Zinc L Carnosine I recomend this site (dr Josh Axe)

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